RG 13022 ( RG 13022;RG-13022.Tyrphostin RG 13022 )

Catalog No. M17260 CAS No. 136831-48-6

RG13022 is a tyrosine kinase inhibitor; inhibits the autophosphorylation reaction of the EGF receptor (IC50: 4 μM).

Purity : 98%

COA

Datasheet

HNMR

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Biological Information

Product Name

RG 13022
Note

Research use only, not for human use.
Brief Description

RG13022 is a tyrosine kinase inhibitor; inhibits the autophosphorylation reaction of the EGF receptor (IC50: 4 μM).
Description

RG-13022 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 1 μM in HT-22 cells. Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs.
Synonyms

RG 13022;RG-13022.Tyrphostin RG 13022
Pathway

Others
Target

Other Targets
Recptor

EGFR
Research Area

——
Indication

——

Chemical Information

CAS Number

136831-48-6
Formula Weight

266.29
Molecular Formula

C16H14N2O2
Purity

98%
Solubility

——
SMILES

COc1c(cc(cc1)/C=C(\C#N)/c1cnccc1)OC
Chemical Name

3-Pyridineacetonitrile, alpha-((3,4-dimethoxyphenyl)methylene)-

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Yoneda T,et al. The antiproliferative effects of tyrosine kinase inhibitors tyrphostins on a human squamous cell carcinoma in vitro and in nude mice. Cancer Res. 1991 Aug 15;51(16):4430-5.

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