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RG 13022

CAS No. 136831-48-6

RG 13022 ( RG 13022;RG-13022.Tyrphostin RG 13022 )

Catalog No. M17260 CAS No. 136831-48-6

RG13022 is a tyrosine kinase inhibitor; inhibits the autophosphorylation reaction of the EGF receptor (IC50: 4 μM).

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 72 In Stock
25MG 170 In Stock
50MG 288 In Stock
100MG 455 In Stock
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Biological Information

  • Product Name
    RG 13022
  • Note
    Research use only, not for human use.
  • Brief Description
    RG13022 is a tyrosine kinase inhibitor; inhibits the autophosphorylation reaction of the EGF receptor (IC50: 4 μM).
  • Description
    RG-13022 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 1 μM in HT-22 cells. Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs.
  • Synonyms
    RG 13022;RG-13022.Tyrphostin RG 13022
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    EGFR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    136831-48-6
  • Formula Weight
    266.29
  • Molecular Formula
    C16H14N2O2
  • Purity
    98%
  • Solubility
    ——
  • SMILES
    COc1c(cc(cc1)/C=C(\C#N)/c1cnccc1)OC
  • Chemical Name
    3-Pyridineacetonitrile, alpha-((3,4-dimethoxyphenyl)methylene)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Yoneda T,et al. The antiproliferative effects of tyrosine kinase inhibitors tyrphostins on a human squamous cell carcinoma in vitro and in nude mice. Cancer Res. 1991 Aug 15;51(16):4430-5.
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